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A key future challenge, therefore, is to understand how the context dictated by cell type, metabolic state, and microenvironmental signals determines the functional outcome of lactylation, enabling the design of interventions that selectively target its pathogenic roles

It reflects the threshold where copper peptides demonstrate follicle-stimulating activity without triggering the inflammatory cascade that copper overload produces

These include vaccine-based and immune-stimulatory approaches evaluated in the adjuvant setting, such as booster peptide vaccination in previously vaccinated patients with resected melanoma (NCT01989559, completed) and a randomized phase III trial testing sargramostim (GM-CSF), peptide vaccination, or their combination following surgical resection of high-risk disease (NCT01989572, completed)

doi: 10.3390/nu9050437 172