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More recently, a study in female SKH-1 hairless mice showed that the topical application of polyphenol-rich extracts of fermented and unfermented rooibos, prior to ultraviolet B-induced tumour promotion and after DMBA-initiated skin cancer, reduced the number of tumours per mouse by 91.39% and 75.37%, respectively, and also the tumour volume by 97.28% and 90.74%, respectively [268]

Lysosome-dependent cell death (LCD) is a subroutine of RCD initiated by perturbations in intracellular homeostasis and demarcated by the release of hydrolytic enzymes into the cytosol following lysosomal membrane permeabilization (LMP) [3, 76, 177]

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After 24 h of adherent growth, the cells were exposed to the samples