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Sphingosine-1-phosphate (S1P) pathway also seems to be upregulated in astrocytes in active and chronic MS lesions through an increase in the S1P receptors, S1P1 and S1P3 (114)

This antioxidant effect helps protect cells from oxidative stress and may contribute to healthy aging

The second, the sleep homeostasis mechanisms, that control the duration of sleep, yet are less well defined

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