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Study design RCTs, systematic reviews, meta-analyses, observational studies, and mechanistic preclinical studies

Conversely, certain BAs, such as lithocholic acid, have been shown to possess anti-cancer properties

Samples were randomly assigned to control or experimental groups, and the investigators were blinded to the experimental conditions

In this condition, the NADH: NAD + ratio in the mitochondria increases due to the reduction in NADH oxidation rate in the respiratory chain (Simon and Hertig, 2015)