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A similar effect on TAG level has also been reported in 293HEK cells (62), while expression of desnutrin/ATGL in 3T3-L1 adipocytes has been shown to increase both glycerol and FA release (144)

similarly showed statistically significant improvement in knee symptoms and daily activity using the Tegner Lysholm Knee Scoring Scale (TLKSS) score in 126 patients with degenerative meniscus lesions and cartilage injuries after 3 months and 6 months of follow up (i.e., TLKSS: 61.9 7.4 baseline, 83.5 4.6 post- 3 months, 83.4 4.3 post- 6 months, p = 0.00065)

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To further determine the biological functions of this system, multi-dimensional experimental validation was conducted using cells, in vitro experiments, and in vivo evaluations on mice