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PAF C-16 binding to PAFR also causes the activation of cytosolic phospholipase A 2 (cPLA 2 ) due to increased levels of intracellular Ca 2+ (Ishii and Shimizu, 2000)

Most notably, and in line with our measurements in bulk AT (Fig

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On the other hand, E2 is also involved in the differentiation of diverse types of normal tissues, being critical to the generation of lobular-alveolar cells and the development of galactophorous ducts (Gompel et al., 2004)