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New Insights on Muscle Strength: The Role of Inhibiting an Enzyme that Hinders NAD+ Synthesis University of Texas Medical Branch researchers show that treating with an inhibitor of an enzyme that breaks down an NAD+ precursor enhances muscle strength and endurance and shortens recovery time in aged mice

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Metformin interferes with vitamin B12 absorption in the terminal ileum, with approximately 10-30% of patients on long-term therapy developing biochemically low or low-normal B12 levels