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5.7 Lipid accumulation: metabolic reprogramming and immune suppression Metabolic reprogramming in colorectal cancer profoundly alters lipid metabolism, transforming lipid species from energy storage molecules into potent immunoregulatory signals that actively shape the immunosuppressive tumor microenvironment through multifaceted mechanisms ( Figure 3 )

Xie Y, Zheng JY, Hou YJ, Li JH, Liu WH, Sun X, et al

CMV causes IL-6 mediated damage to the TJs in the intestinal epithelial cells, which leads to a decrease in the transepithelial electrical resistance and an increase in their permeability [96]

TRAF2, Tumor Necrosis Factor Receptor Associated Factor 2