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Cd toxicity also induces the upregulation of glutathione peroxidase (Gpx) expression and decreases the activity of glutathione reductase ( On the other hand, Co triggers DNA methylation in Vicia faba seeds (Rancelis et al., 2012) while Cu is harmful to young sunflower plants, causing oxidative stress by producing ROS and reducing catalase activity (Pena et al., 2011)