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By your third to fifth session, the difference is usually striking

J Chem Theory Comput 2, 364382 (2006)

doi: 10.1038/nclimate2470 9 AthukoralaY.LeeK

The solid was then collected by centrifugation at 10,000 rpm for 20 min, followed by washing with distilled water three times and dried in a vacuum oven for 16 h at 80 C