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MPTP, which selectively damages nigrostriatal dopaminergic neurons through its metabolite MPP + , is a commonly used model for studying the pathological mechanisms of PD

Combination of antioxidant enzymes with this natural carrier not only delayed their degradation (i.e

Lifestyle-based strategies, including caloric restriction, antioxidant-rich diets, regular physical activity, and adequate sleep, help maintain metabolic balance, reduce oxidative stress, and enhance autophagic turnover, thereby supporting circadian synchrony and systemic homeostasis [24,25]