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Fumarate, also an intermediate metabolite of the TCA cycle, conventionally links arginine metabolism to glucose-generated energy metabolism

10.1111/j.1574-695X.2012.00981.x 106

In 60% of patients with epilepsy, symptoms are initiated by structural causes, such as traumatic brain injury (TBI) or stroke (1, 11), which are generally considered change blood-brain barrier (BBB) permeability

doi: 10.3389/fphar.2022.1071897 Received 17 October 2022 Accepted 16 November 2022 Published 24 November 2022 Volume 13 - 2022 Edited by Chunpeng (Craig) Wan, Jiangxi Agricultural University, China Reviewed by Hui Wang, University of Massachusetts Medical School, United States Fei Yuan, Baylor College of Medicine, United States Updates Copyright 2022 Zhang, Lei, Huang and Wang