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To confirm the neutralizing activity of the anti-VEGF antibody in vivo, Miles microvascular permeability assays were performed in mice and guinea pigs as previously described (26), using 50 ng of murine VEGF164 for intradermal injections

it documents a claimed invention and supporting examples, but it does not undergo the independent scrutiny, pre-registration, blinding, and statistical reporting that define credible clinical evidence

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