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10.1016/j.carbpol.2021.118607 161 YangR.LiuX.RenY.XueW.LiuS.WangP.et al (2021b)

These findings might provide a reference value for the utilization of CAT as supplement for mother from late pregnancy to lactation period to promote the fatty acid metabolism of offspring

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CRC cells frequently remodel their TCA cycle due to mutations (KRAS, TP53), hypoxia, or dysregulated signaling, leading to intracellular accumulation and extracellular release of specific intermediatesincluding succinate, fumarate, itaconate, and -ketoglutarate (-KG)which function as potent immunometabolites by directly modulating immune cell metabolism, epigenetic programming, and signaling pathways ( Figure 3 )