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The compound significantly enhances the effectiveness of gemcitabine in intrahepatic cholangiocarcinoma by inhibiting HDAC activity and restoring expression of pro-apoptotic genes (81)

KPV has an unusually well-defined mechanism (PepT1 uptake, NF-B/MAPK inhibition) and reproducible anti-inflammatory effects in mouse colitis models

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After 52 weeks of once weekly Zepbound (10 or 15 mg) or placebo, participants on Lillys drug experienced a statistically significant and clinically meaningful reduction in apnea or hypopnea events