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To understand how Cellular Therapy and Stem Cells for MCTD can provide relief and regeneration, it is vital to examine the key cellular players involved in MCTD pathogenesis: T Lymphocytes (CD4 and CD8): These immune cells drive inflammation and tissue damage by recognizing autoantigens and releasing destructive cytokines

Secretion of IFN, IL-17, and IL-22 by Th1 and Th17 cells activates B cells, which secrete anti-tTG, anti-neo-tTG, and anti-endomysial autoantibodies (EMA)

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Our analysis also indicated that over 10% of Korean older patients received greater than 10 mg S-CIT daily doses together with CYP2C19 inhibitors, exposing older patients to an elevated risk of adverse events from DDI (Figure 1)