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It was later proposed that this carcinogen from cigarette smoke adsorbed onto the surfaces of asbestos fibres may enhance the presentation of this carcinogenic compound to cellular constituents and thus play some part in the overall biological activity of the inhaled fibres [297]

For instance, empirical evidence shows that rat hepatocytes begin ROS production after the first 30 minutes of DEM exposition (5 mM), growing linearly for all the remaining time, whereas the increase in products of lipid peroxidation (TBARS) starts only from the first hour of exposure (Tirmenstein et al

M., Moniz, T., Silva, A

In the early stage of tumor colonization or growth, activated immune cells contribute to a tumor-suppressive inflammatory microenvironment that hinders tumor development, whereas long-term persistent antigenic stimulation, the activation of immunosuppressive cells and metabolic stress prompt the tumor to escape from the surveillance of the immune system and continue to grow, which is known as immune escape of the tumor (70,71)