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Preclinical and clinical evidence indicates that toxins derived from hematomas can induce neuronal death through ferroptosis

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10.1002/cpt.161 18 SomkruaR.EickmanE

The increased urea induces the decreased expression of tight junction proteins, including claudin-1, occludin and zonula occludens-1 (ZO-1), which results in the disruption of intestinal epithelial tight junction (Vaziri et al., 2013)