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(ii) For performance year 2025 and subsequent performance years, if an ACO reports all of the required measures in the APP Plus quality measure set, meeting the data completeness requirement at 414.1340 of this subchapter for each measure in the APP Plus quality measure set, and receiving a MIPS Quality performance category score as described at 414.1380(b)(1) of this subchapter, for the relevant performance year, and the ACO meets either of the following: (A) The ACO's total available measure achievement points used to calculate the ACO's MIPS Quality performance category score are reduced under 414.1380(b)(1)(vii)(A) of this subchapter

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Even a slight elevation in ROS levels within cancer cells relative to that in normal cells can surpass a critical threshold, inducing cancer cell death and suppressing tumor development [9]