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(2019) Observation of complex formation between L-histidine and heterocyclic compounds in water and aqueous buffer solution using calorimetric and spectroscopic methods

While we don't have large IV studies yet, the biological rationale is rock-solidreplenishing glutathione could help break this destructive cycle

Remarkably, the effect of the IIS pathway seems to be confirmed also in centenarian humans, where genetic alterations in the IGF1R gene are associated with increased longevity (Suh et al., 2008)