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Intriguingly, the FGF-2-FGFR1 signaling in endothelial cells induces expression of PDGF-B and PDGF-D to ensure activation of perivascular PDGFR, which is the common receptor for PDGF-B and PDGF-D and crucial for pericyte recruitment 24

Long-term iron chelation or continuous GPX4 activation might protect against cell death but at the cost of interfering with essential processes like erythropoiesis and mitochondrial respiration [352]