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Dynamics of the proteome and remodeling of extracellular vesicles in red blood cells Red blood cells demonstrate dynamic proteome remodeling despite the absence of nuclei and protein synthesis capabilities, principally by protein modification, selective destruction, and the shedding of extracellular vesicles (EVs) (38, 39)

I still feel bloated and no change in anything else

HRD1 directs a fraction of nascent POMC to the ERAD and prevents POMC aggregate accumulation, ensuring that other POMC fractions undergo proper posttranslational maturation and transport for secretion