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Despite its critical importance, sulfur depletion is common, particularly in states of chronic illness, high oxidative stress, or prolonged systemic inflammation, where the body's metabolic demands rapidly outpace dietary intake

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doi: 10.1016/j.cell.2020.02.016

Overall, our results suggest that DA functions uniquely at 2A -adrenergic receptors as a G protein-biased agonist by selectively directing intracellular signaling towards G protein-mediated transduction pathways