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While the therapeutic peptide field blew up after insulin was introduced in the 1920s, it hit a major roadblock in the 1980s due to poor stability and high production costs

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Severe patients with COVID-19 more frequently had increased inflammatory monocytes and neutrophils and a sharp decrease in lymphocytes (Giamarellos-Bourboulis et al., 2020), with higher levels of IL-1, IL-6, and TNF- (Chen G

Notably, nanocarriers such as gold nanoparticles loaded with miR-21-3p synergize with immune checkpoint inhibitors by disrupting redox balance and sensitizing tumors to ferroptosis [125]