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Tirzepatide, a dual-agonist peptide, has shown significant results with a 22.5% weight loss over 72 weeks at a 15 mg dose (Jastreboff et al., NEJM), making it one of the most effective therapies for obesity

However, the treatment with Daratumumab leads to a rapid elimination (85~90%) of CD38 + NK cells, lasting up to 6 months after the treatment [94, 120]

Mechanisms of action Anti-CD38 antibodies exert their therapeutic effects via direct effector mechanisms on MM cells (i.e., CD38 enzymatic inhibition, direct induction of apoptosis) and through Fc-dependent immune mechanisms, including antibody-dependent cellular cytotoxicity (ADCC), complement-directed cytotoxicity (CDC), and antibody-directed cellular phagocytosis (ADCP) (Fig

The most common types include: Cyanocobalamin Methylcobalamin Hydroxocobalamin Each type varies in absorption rate, duration, and suitability