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In some embodiments, the use of multiparticulates (e.g., micronized particles) of a therapeutic agent, or an otic agent, allows for extended and/or sustained release of the therapeutic agent from any formulation described herein compared to a formulation or composition comprising non-multiparticulate (e.g., non-micronized) therapeutic agent

This is because of their exceptional physicochemical properties, including a high surface area, straightforward synthesis and modification, and the ability to activate brain immune responses

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Additionally, targeting both c-Met and FGFR pathways provides superior suppression of HCC progression (Jo et al., 2015)