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In addition, pyruvate, a key glycolytic metabolite generated by pyruvate kinase muscle 2 isoform (PKM2), directly supports the DDR by facilitating -H2AX loading through the FACT (facilitates chromatin transcription) complex, thereby promoting DNA repair efficiency and conferring radioresistance [75]

Ching Department of Public Health, Administration, and Social Sciences, Cayetano Heredia University, Lima, Peru Jesus Lorenzo Chirinos-Caceres Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China William C

however, several other studies found contradicting results, whereby the search for reliable and specific HIV latency biomarkers in resting CD4 + T cells is ongoing [57,58,59,60,61,62]