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3.2.1 TGVS theory According to the TGVS theory, which combines blood vessels, nerves, and neurotransmitters, the trigeminal nerve and peri-vascular nerve fibers both inside and outside the skull serve as the main pathways for transmitting pain in migraines

The peptide operates through multiple interconnected signaling cascades rather than binding to a single identified receptor, which distinguishes it from many pharmaceutical compounds