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Handy, D.E

The findings indicated that HRV measurements taken before ascent under normal oxygen conditions had superior diagnostic accuracy for AMS compared to all HRV measurements and peripheral oxygen saturation monitoring during hypoxia, thus affirming the predictive role of HRV assessment both before and during expeditions for AMS susceptibility at high altitudes, with its diagnostic accuracy surpassing SpO2 monitoring

Together, these finding indicate that the toxic effects of DOX on the heart are strongly associated with iron overload and ferroptosis in mitochondria, indicating that targeting ferroptosis could serve as a promising therapeutic strategy for protecting the hearts of cancer patients from DOX-induced cardiomyopathy

Mapson LW, Isherwood FA (enero de 1963)