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Poston CN, Krishnan SC, Bazemore-Walker CR

Thus, it was suggested that fluoxetine can regulate estrogen synthesis/signaling and cause dysregulation of the estrous cycle, thereby causing sexual dysfunction (Figure 3) ( Figure 3) ( 5 Effects of SSRIs on the reproductive system of aquatic organisms SSRIs are a major class of drugs of environmental concern, and fluoxetine, a psychoactive agent, is one of the best-selling prescription antidepressants in the world, which increases the likelihood of aquatic environmental contamination through municipal, industrial, and hospital discharges, potentially inducing sublethal effects in non-target species

Institute of Medicine (IOM) recommended dietary intake or the European Food Safety Authority (EFSA) adequate intake

It is believed that ICD is responsible for communication between the TMD and NBD.