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In general, patients with liver disease are not more susceptible to drug-induced hepatotoxicity

In mitochondria, ROS are generated predominantly at electron transport chain (ETC) complexes and through electron leakage, resulting in the partial reduction of molecular oxygen and the formation of superoxide anion O 2 [175]

Dong-Hua Yang, [email protected] These authors have contributed equally to this work This article was submitted to Cancer Molecular Targets and Therapeutics, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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