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The most modulated genes found through the network approach were SIRT3, FOXO1, and PPARGC1A, these proteins were also found to have the highest docking results, several studies have reported the role of these proteins in the modulation of ROS and oxidative stress via mitochondria, as ROS and oxidative stress have been reported to alter various cellular signaling pathways and cause neuronal death

K., Majumder, P

Then, the most outstanding biomarkers were incorporated into a model for case-detection and prediction for screening purposes ( As part of the biomarker exploration component of this project, biomarkers of the functional psychosis model were examined for their predictive translational relationships

In vivo, SLU-PP-332 increases oxidative fiber markers (for example, type IIa), cytochrome-c content, mitochondrial DNA abundance, and expression of OXPHOS genes