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Previous studies have well-documented the direct interaction between APP-generated reactive species and isolated proteins, along with their significant impacts on protein functionality 48

Cellular redox signaling, influenced by fluctuations in ROS, RNS, and antioxidant systems, governs vital functions like cell growth, programmed death, and immune responses [112]

Research has demonstrated that glutamate dehydrogenase (GLUD1) is expressed at a high level in lung adenocarcinoma cells, and lysine 503 (K503) has been identified as the primary ubiquitination site of GLUD1