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Drug delivery systems based on HA also face difficulties with controlling release kinetics, ensuring efficient cellular uptake, and overcoming tumor heterogeneity, as not all cancer cells overexpress CD44 receptors targeted by HA conjugates

Fernando N, Wong JHC, Das S et al (2020) MicroRNA-223 regulates retinal function and inflammation in the healthy and degenerating retina

Consequently, gene-edited liver cells can be expanded ex vivo and then transplanted into the patient, where they can continue to grow and function without eliciting an excessive immune response

Four studies demonstrated improvements that met or exceeded the lower bound for clinical relevance