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Some people use microdosing during initial titration to minimize side effects

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doi: 10.1186/s12974-021-02252-6 273 RaaschJ.ZellerN.van LooG.MerklerD.MildnerA.ErnyD.et al

Nucleus pulposus cells, while theoretically most advantageous due to their ability to adapt to the harsh intradiscal environment and synthesize specific matrix, are limited in number in degenerated discs, their acquisition is invasive, and they are difficult to use for repairing the annulus fibrosus and endplate, limiting clinical application