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In summary, trauma to the upper GI tract during surgery is a major reason for black stool after surgery

In gastrointestinal lesions (indomethacin (30 mg/kg s.c.), aspirin (400 mg/kg i.g.) and diclofenac (125 mg/kg i.p.)) studies, NaBPC157 (10 g or 10 ng/kg i.p.) was given regularly, either simultaneously and/or one hour prior to drug application (indomethacin)

Although strategies such as continuous-flow synthesis show promise, further systematic validation across multiple CQD systems and production scales is required to establish their general applicability