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The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms

Brain Res 1726:146423

Complementary studies using primary immune cells and tissue-specific models are essential to elucidate how MTHFR-related methylation changes translate into functional dysregulation of the immune system

This dynamic modulation not only contributes to the overall resilience of the gut ecosystem but also hints at Rutins potential to maintain the delicate balance between microbial diversity and stability