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Heritable connective tissue disorders have historically been considered rare, with an anecdotal figure of 1: 5000 often quoted

Thus, the PER2-dependent mechanism disrupts AKT proteostasis, potentially altering cell fate

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Of interest, direct exposure of dorsal hippocampus to the effect of Homocysteine does not cause direct neurotoxicity, though co-administration of Homocysteine with glutamate agonists like kainic acid induces more neurotoxicity (Mller et al