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Methotrexate (MTX) is frequently used as the anchor drug in multi-drug regimens used for management of rheumatoid arthritis (Cohen & Mikuls, 2025

Beijing: China National Intellectual Property Administration

The MannWhitney U test, Wilcoxon test, and KruskalWallis test were used for nonparametric analysis

Intriguingly, MOTS-c behaves like an exercise mimetic in muscle: it is an exercise-induced peptide, meaning that during physical activity the levels of MOTS-c naturally rise