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Despite strong preclinical evidence, further dose-response and clinical trials are warranted

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Hence MetALD patients are at the intersection of MASLD and ALD, it is obvious that within the MetALD group the contribution of MASLD and ALD will vary

Introduction Chemical inducers of proximity (CIPs) include bifunctional small molecules and molecular glues that induce proximity between two targets, often leading to neomorphic effects that can be leveraged to re-wire biological circuits, which is difficult to achieve with other pharmacological approaches 1,4