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Oxidative DNA damage can lead to global hypomethylation or locus-specific changes [49,50,51,52,53], while histone modification, such as reduced H3K4 methylation and altered acetylation of H3 and H4 residues affect the expression of genes controlling antioxidant defense and mitochondrial function [54,55,56,57,58,59]

In addition, the clonal proliferation assays illustrated that KBiF 4 @HSA alone did not significantly impact cell colony formation (Fig

BC-derived IL-6 activates STAT3 in lung lymphatic endothelial cells (LECs), upregulating CCL5 and vascular endothelial growth factor (VEGF) to promote tumor cell recruitment, extravasation, and colonization [142]