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GHRP-2 and MK-677 may benefit from periodic breaks (4-6 weeks off every 6 months) to prevent receptor desensitization

Julius D, Blair L, Brake A, Sprague G, Thorner J (1983) Yeast alpha factor is processed from a larger precursor polypeptide: the essential role of a membrane-bound dipeptidyl aminopeptidase

These results are consistent with the previous report that replacement of Ser 3P by a charged amino acid (Lys) or small hydrophobic residues (Val, Leu, or Ile) significantly decreased ghrelins activity 29