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Common side effects Injection-site reactions: mild redness, tenderness, swelling, occasional bruising - usually resolve within hours Skin flushing / warmth - brief, related to vasodilation Transient fatigue in the first 12 weeks of intensive protocols Mild headache - usually dose-related Higher-dose theoretical concerns Copper accumulation - each 2 mg injection adds roughly 0.03 mg of elemental copper, trivial next to the 0.92.2 mg from a normal diet

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Richards, T., et al

These data imply that the distribution and extent of MAMs in the dendrites may regulate Ca 2+ dynamics and thus, determine the properties of synaptic integration and plasticity at the dendrites [62]