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Description

The activity of xCT is decreased in HD leading to suboptimal cystine metabolism ( N -acetyl cysteine (NAC) in the diet of R6/2 mice alleviated some of the symptoms and delayed disease progression

10.1016/j.jep.2014.01.040 179 XiangQ.-Y.BrunsfeldS.SoltisD.SoltisP

Author contributions Conceptualization, VS

The redox-active iron form (Fe 2+ ) oxidizes lipids, in the Fenton reaction, which results in the production of a large amount of ROS, further oxidation of DNA and proteins are mediated by ROS, which results in insulin synthesis and secretion reduction, and ultimately apoptosis [45] (Fig