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For the control group, normal saline, which was dissolved in 2% dimethylsulfoxide (DMSO), was administered to the animal model and the treatment group, which were further separated into three different groups, were given three different doses of poncirin (5, 15 and 30 mg/kg) to identify whether the poncirin could reduce the damage caused by CCl4 administration

The introduction of liposomes not only significantly improves the stability and bioavailability of SB, but also realizes the regulation of the drug release process

Subsequently, German internist Arnold Cahn (1858-1927) and German physician and physiologist Josef Freiher von Mering (1849-1908), working in the Strassburg clinic of German physician Adolf Kubmaul (1822-1902), showed that a patient with pernicious anemia had no hydrochloric acid in the stomach contents, a finding later demonstrated to be pervasive in this disorder and to precede the development of anemia (139)

One of the widely tested drugs is Bexarotene, which is an RXR/LXR agonist that initially showed promising results in animal models of AD, increasing amyloid clearance and improving behavioral deficits [208, 209]