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In vivo assessments demonstrated that AANLCs significantly reduced tumor volume (3.30 0.23 cm 3 ) and weight (5.37 0.41 g), enhanced cytotoxicity (92.36%), and improved survival outcomes (49.66 days), compared to the free drug administered as suspension (0.25%w/v Na-CMC) (42 days)

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Induction of microsomal enzymes can occur with: Biphenylles with polychlor DDT and some insecticides Benzopyrenes and other polycyclic aromatic hydrocarbons (products of burned coal and petroleum products) Polycyclic hydrocarbons in the cigarette smoke can induce some enzymes like CYP1A2 and CYP1A1 (For this reason, the metabolism rate of chlorpromazine, theophylline and imipramine is significantly high in heavy smokers)

The glucose and glutamate drops (close to 20%) around 45 h were not well-predicted by both ANN (data not shown) and PLS