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Moreover, the combination of etomoxir and orlistat, a FASN enzyme inhibitor, had an additive effect on MM cell viability inhibition, through the reduction of p21 protein levels and the phosphorylation of Rb

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Hyperactivity of medial prefrontal cortex pyramidal neurons occurs in a mouse model of early-stage Alzheimers disease without -amyloid accumulation

After 24 h, the medium was replaced by low-serum medium (0.5% for murine melanoma cell lines and 1% for human melanoma cells) and the cells were incubated for a further 18 h before stimulation with 10 nM GRP (4011670 bachem) and/or 1 M RC (R9653, Sigma-Aldrich) for 48 h