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Researchers designing protocols based on this escalation data should reference the published Phase 2 data while monitoring Phase 3 publications for refinements

Initial Metabolic Changes (Days 1-14): While cellular-level metabolic changes begin within hours of the first AOD-9604 administration, noticeable subjective effects typically emerge within the first one to two weeks

These findings suggest that targeted inhibition of CD38 ecto-enzymatic activity could be a potential pharmacological approach for SSc fibrosis treatment