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Diabetes (2014) 63:383545

In the Gclm / mouse model of schizophrenia, we found increased Gln/Glu in the frontal cortex (relative to both +/+ and +/ mice), without a reduction of glutamate but an increase in glutamine levels [76, 82, 84]

doi: 10.1210/endocr/bqaa204 69 LateefOMAkintubosunMO

Oxidative Stress An imbalance between free radicals and antioxidants damages cells and DNA, depleting folate levels and reducing glutathione, an essential detoxifier