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Not by directly increasing testosterone levels

DNA methylation systematically restructures cellular metabolic networks by silencing or activating specific sets of genes, including markers of thyroid differentiation (e.g., TSHR, NIS) and key metabolic enzymes in glucose, lipid, and amino acid pathways

They also reported that both serum N-terminal procollagen type III concentration and UAC were higher in cavalier King Charles spaniels than in other breeds when other measured variables were controlled for